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MIF demonstrates chemokine-like purpose and was identified being a ligand of both CXCR2 and CXCR4. Binding of MIF to those receptors enhances monocyte recruitment and leukocyte chemotaxis (Figure 1). In human chondrosarcoma cells, this recruitment is mediated by G?i proteins and PI3K in T cell adhesion by upregulation of the transcription on the ?v